Endocrine Abstracts

Background: Male hypogonadism is a frequent reason for referrals to secondary care. Work up and approach to diagnosis and treatment varies among practicing physicians and proper work up and monitoring is crucial for safe and effective Testosterone replacement therapy (TRT). Methods: Retrospective case reviews for all men who were prescribed TRT via secondary care endocrine unit between September 2021 and September 2022.<...

Background: There exists low confidence in prescription of multiple daily injections (MDI) for newly diagnosed Type 1 Diabetes Mellitus paediatric patients among paediatric doctors at Basildon & Thurrock University Hospital (BTUH).Aim: To improve the confidence in MDI discharge prescriptions for paediatric doctors of all grades via adaptation of local guidelines.Methods: We des...

Summary: Simpson Golabi Behmel Syndrome (SGBS) is a rare syndrome characterized clinically by multiple congenital anomalies, pre and postnatal overgrowth, characteristic craniofacial anomalies, macrocephaly, and organomegaly associated with abnormalities of the skeletal system. The spectrum of signs and symptoms associated with SGBS is wide, ranging from very mild to fatal forms, especially in affected men. We report a rare case of a child affected by SGBS type 1, emphasizing ...

Introduction and importance: Pseudo-Cushing’s syndrome (PCS) encompasses a spectrum of medical conditions, both physiological and non-physiological, that replicate the clinical features of Cushing’s syndrome (CS). In PCS, there is a presence of mild biochemical hypercortisolaemia, which is carefully regulated by physiological feedback hormonal control mechanisms. Physiological conditions contributing to PCS include factors like pregnancy surgical or emotional stress,...

Introduction: Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome is a rare congenital cause of primary amenorrhea, characterized by aplasia of the vagina with or without concurrent uterine and/or cervical aplasia. MRKH syndrome has a heavy psychological impact, and requires multidisciplinary management.Case Report: A 17-year-old female patient presented for exploration of a primary amenorrhea. Her medical history was significant for recurrent urinary tr...

Noradrenaline (NE) is a peripheral vasoconstrictor reducing mortality by 11% and major adverse events by two-thirds compared to dopamine [1]. NE acts as an agonist at alpha1 and beta1 receptors, with little-to-no beta2 or alpha2 activity. This vasoconstriction effect can be potent and can result in completely occluded blood vessels more frequently in the peripheries due to lower blood pressure. Septic shock accounts for nearly 1 in 10 admissions to ICU, where it is the most co...

• A 54-year old Lithuanian man presented with symptomatic hyperglycaemia and weight loss.• A diagnosis of new onset diabetes type 2 was confirmed for which he received treatment. In addition, his serum potassium remained low despite of intervention.• CXR was done and showed a bulky right sided hilar mass.• The combination of refractory hypokalaemia, hyperglycaemia, and lung cancer suspicio...

Background: Hyperinsulinemic hypoglycaemia (HH) after Roux-en-Y gastric bypass (RYGB) is rare. Patients typically present with post-prandial hypoglycaemia >1 year after surgery and once weight loss has plateaued. Despite multiple treatment options, the management of these patients remains challenging.Clinical case: A 31-year-old female was referred for bariatric surgery with a BMI of 41.4 kg/m2. In the year preceding the r...

Background and Aim: Type 2 diabetes mellitus (T2DM) disparately affects ethnic groups. Prevalence is higher in Asian and Black ethnicities, and these patients suffer increased rates of some diabetes-related complications. Bariatric surgery is an effective treatment for T2DM and can lead to complete diabetes remission. The aim of this study was to assess if T2DM remission rates at 1-year following bariatric surgery vary between different ethnicities.Metho...

Introduction: Checkpoint inhibitors (CPi) are finding a place in the treatment algorithm of an increasing number of cancers. Immune-related (ir) endocrinopathies are frequent side-effects. Diabetes mellitus (irDM) is infrequent, but often presents acutely and can be potentially life-threatening There are ˜60–70 cases characterising irDM in the literature. We describe 4 cases of irDM to add to the understanding of this condition. All four patients were undergoing trea...